MolNFT v1 · #108727 · protein
Coxsackievirus B3 polymerase - F232L mutant - AMSO4 crystal form
4WFY · RNA-directed RNA polymerase: “Coxsackievirus B3 polymerase - F232L mutant - AMSO4 crystal form”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.64). MolNFT v1 #108727 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4WFY
- Type
- protein
- Length
- 462 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase
- EC
- 2.7.7.48
- UniProt
- P03313
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase (EC 2.7.7.48) | protein | 462 | 42% helix, 15% strand | P03313 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 464 | 0.64 | 0.77 | 48 | SO4 |
| 2 | 224 | 0.58 | 0.79 | 27 | empty |
| 3 | 78 | 0.42 | 0.80 | 19 | empty |
| 4 | 93 | 0.37 | 0.75 | 17 | GOL, SO4 |
Compared structures
- 4WFY · Coxsackievirus B3 Polymerase - F232L Mutant - AmSO4 Crystal Form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03313
- Elsewhere: RCSB PDB 4WFY · PDBe 4WFY · UniProt P03313
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.