MolNFT v1 · #108684 · protein
Co-complex structure of the F4 fimbrial adhesin faeg variant ac with llama single domain antibody V1
4WEM · K88 fimbrial protein ac: “Co-complex structure of the F4 fimbrial adhesin faeg variant ac with llama single domain antibody V1”. X-ray diffraction, 1 ligand (PO4), 2 pockets (best druggability 0.46). MolNFT v1 #108684 on GenesisL1…
- PDB
- 4WEM
- Type
- protein
- Length
- 369 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- K88 fimbrial protein ac; Anti-F4+ETEC bacteria vhh variable region
- UniProt
- L7XD53, R9W2R6
- Ligands
- PO4
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | K88 fimbrial protein ac | protein | 248 | 9% helix, 46% strand | L7XD53 |
| B | Anti-F4+ETEC bacteria vhh variable region | protein | 121 | 7% helix, 51% strand | R9W2R6 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.46 | 0.76 | 23 | empty |
| 2 | 97 | 0.34 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 830 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4WEM · Co-complex structure of the F4 fimbrial adhesin FaeG variant ac with llama single domain… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L7XD53
- Every structure of UniProt R9W2R6
- Elsewhere: RCSB PDB 4WEM · PDBe 4WEM · UniProt L7XD53 · UniProt R9W2R6
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