MolNFT v1 · #108607 · protein + RNA

Structure of tRNA-processing enzyme complex 1

4WC3 · Poly a polymerase: “Structure of tRNA-processing enzyme complex 1”. X-ray diffraction, 10 pockets (best druggability 0.72). MolNFT v1 #108607 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WC3
Type: protein + RNA
Length: 443 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Poly a polymerase; RNA 76-mer
UniProt: O66728
Pockets: 10 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 58% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Poly a polymerase	protein	367	58% helix, 11% strand	O66728
B	RNA 76-mer	rna	76	—	—

Pockets

10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	954	0.72	0.77	41	empty
2	722	0.71	0.78	52	empty
3	587	0.69	0.78	46	empty
4	417	0.59	0.76	24	empty
5	95	0.38	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 1346 Å² buried · 18 hydrogen bonds · protein-nucleic

Compared structures

4WC3 · Structure of tRNA-processing enzyme complex 1 · the same entry in another collection · chain A against A, TM-score 1.00
O66728 · AlphaFold monomer V2.0 prediction for a-adding tRNA nucleotidyltransferase (O66728) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O66728
Elsewhere: RCSB PDB 4WC3 · PDBe 4WC3 · UniProt O66728

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