MolNFT v1 · #108603 · protein
TRNA-processing enzyme (apo form 2)
4WBZ · Poly a polymerase: “TRNA-processing enzyme (apo form 2)”. X-ray diffraction, 10 pockets (best druggability 0.71). MolNFT v1 #108603 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WBZ
- Type
- protein
- Length
- 714 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Poly a polymerase
- UniProt
- O66728
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Poly a polymerase | protein | 364 | 54% helix, 11% strand | O66728 |
| B | Poly a polymerase | protein | 350 | 54% helix, 11% strand | O66728 |
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1157 | 0.71 | 0.75 | 72 | empty |
| 2 | 280 | 0.51 | 0.74 | 31 | empty |
| 3 | 305 | 0.49 | 0.73 | 33 | empty |
| 4 | 115 | 0.43 | 0.76 | 17 | empty |
| 5 | 65 | 0.42 | 0.81 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 500 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O66728
- Elsewhere: RCSB PDB 4WBZ · PDBe 4WBZ · UniProt O66728
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