MolNFT v1 · #108585 · protein

Crystal structure of the hr-1 domain of human caprin-1 in the C121 space group

4WBE: “Crystal structure of the hr-1 domain of human caprin-1 in the C121 space group”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #108585 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WBE
Type: protein
Length: 359 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caprin-1
UniProt: Q14444
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Caprin-1	protein	120	68% helix, 3% strand	Q14444
C	Caprin-1	protein	119	67% helix, 3% strand	Q14444

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	236	0.58	0.79	30	empty
2	209	0.49	0.75	24	empty

Interfaces

2 interfaces between chains.

B–C · 1706 Å² buried · 23 hydrogen bonds · protein-protein
A–B · 223 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

4WBE · Crystal structure of the HR-1 domain of human caprin-1 in the C121 space group · the same entry in another collection · chain A against A, TM-score 1.00
Q14444 · AlphaFold monomer V2.0 prediction for caprin-1 (Q14444) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14444
Elsewhere: RCSB PDB 4WBE · PDBe 4WBE · UniProt Q14444

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