MolNFT v1 · #108508 · protein

Crystal structure of CMR1 from pyrococcus furiosus bound to a nucleotide

4W8X · CRISPR system cmr subunit CMR1-1: “Crystal structure of CMR1 from pyrococcus furiosus bound to a nucleotide”. X-ray diffraction, 2 ligands (3GP, PO4), 3 pockets (best druggability 0.61). MolNFT v1 #108508 on GenesisL1: 3D structure…

PDB: 4W8X
Type: protein
Length: 329 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRISPR system cmr subunit CMR1-1
UniProt: Q8U1S5
Ligands: 3GP, PO4
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CRISPR system cmr subunit CMR1-1	protein	329	37% helix, 20% strand	Q8U1S5

Ligands and binding sites

3GP · Guanosine-3'-monophosphate · ligand · chains A
PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	233	0.61	0.81	37	PO4, 3GP
2	74	0.58	0.88	19	empty
3	66	0.36	0.77	11	empty

Compared structures

4W8X · Crystal Structure of Cmr1 from Pyrococcus furiosus bound to a nucleotide · the same entry in another collection · chain A against A, TM-score 1.00
Q8U1S5 · AlphaFold monomer V2.0 prediction for CRISPR system cmr subunit CMR1-1 (Q8U1S5) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8U1S5
Elsewhere: RCSB PDB 4W8X · PDBe 4W8X · UniProt Q8U1S5

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