MolNFT v1 · #108440 · protein

Co-complex structure of the lectin domain of F18 fimbrial adhesin fedf with inhibitory nanobody NBFEDF6

4W6W · F18 fimbrial adhesin ac: “Co-complex structure of the lectin domain of F18 fimbrial adhesin fedf with inhibitory nanobody NBFEDF6”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #108440 on GenesisL1: 3D structure…

PDB: 4W6W
Type: protein
Length: 265 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: F18 fimbrial adhesin ac; NBFEDF6
UniProt: Q47212
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	F18 fimbrial adhesin ac	protein	141	6% helix, 62% strand	Q47212
B	NBFEDF6	protein	124	9% helix, 48% strand	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.54	0.81	29	empty

Interfaces

1 interface between chains.

A–B · 761 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4W6W · Co-complex structure of the lectin domain of F18 fimbrial adhesin FedF with inhibitory… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q47212
Elsewhere: RCSB PDB 4W6W · PDBe 4W6W · UniProt Q47212

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