MolNFT v1 · #108326 · protein

Structural and functional characterization of a novel monotreme- specific protein from the milk of the platypus

4V3J · Monotreme lactating protein: “Structural and functional characterization of a novel monotreme- specific protein from the milk of the…”. X-ray diffraction, 1 ligand (NAG), 3 pockets (best druggability 0.76). MolNFT v1 #108326 on…

PDB: 4V3J
Type: protein
Length: 345 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Monotreme lactating protein
UniProt: F6UME2
Ligands: NAG
Pockets: 3 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Monotreme lactating protein	protein	345	55% helix, 3% strand	F6UME2

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.76	0.99	19	empty
2	112	0.44	0.78	20	empty
3	124	0.43	0.76	16	empty

Modifications

Observed in the structure: 3 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

4V3J · Structural and functional characterization of a novel monotreme- specific protein from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F6UME2
Elsewhere: RCSB PDB 4V3J · PDBe 4V3J · UniProt F6UME2

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