MolNFT v1 · #108283 · protein

Human UNC5A ectodomain

4V2A · Netrin receptor UNC5A: “Human UNC5A ectodomain”. X-ray diffraction, 1 ligand (NAG), 2 pockets (best druggability 0.32). MolNFT v1 #108283 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4V2A
Type: protein
Length: 248 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Netrin receptor UNC5A
UniProt: Q6ZN44
Ligands: NAG
Pockets: 2 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Netrin receptor UNC5A	protein	248	4% helix, 42% strand	Q6ZN44

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.32	0.75	15	empty
2	52	0.28	0.75	14	empty

Modifications

Observed in the structure: 6 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

4V2A · human Unc5A ectodomain · the same entry in another collection · chain A against A, TM-score 1.00
Q6ZN44 · AlphaFold monomer V2.0 prediction for netrin receptor UNC5A (Q6ZN44) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6ZN44
Elsewhere: RCSB PDB 4V2A · PDBe 4V2A · UniProt Q6ZN44

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.