MolNFT v1 · #108241 · protein
The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-684)
4V0X · Protein phosphatase PP1-gamma catalytic subunit: “The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-684)”. X-ray diffraction, 1 ligand (MN), 1 pocket (best druggability 0.35). MolNFT v1 #108241 on…
- PDB
- 4V0X
- Type
- protein
- Length
- 317 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase 1 regulatory subunit…
- EC
- 3.1.3.16
- UniProt
- P63087, Q5SWA1
- Ligands
- MN
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein phosphatase PP1-gamma catalytic subunit (EC 3.1.3.16) | protein | 293 | 34% helix, 20% strand | P63087 |
| B | Protein phosphatase 1 regulatory subunit 15B | protein | 24 | 0% helix, 29% strand | Q5SWA1 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.35 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1462 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 4V0X · The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-684) · the same entry in another collection · chain A against A, TM-score 1.00
- P63087 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase PP1-gamma… · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q5SWA1 · AlphaFold monomer V2.0 prediction for protein phosphatase 1 regulatory subunit 15B… · a predicted model of the same protein · chain B against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63087
- Every structure of UniProt Q5SWA1
- Elsewhere: RCSB PDB 4V0X · PDBe 4V0X · UniProt P63087 · UniProt Q5SWA1
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