MolNFT v1 · #108220 · protein

Dimeric pseudorabies virus protease PUL26N at 2.1 a resolution

4V07: “Dimeric pseudorabies virus protease PUL26N at 2.1 a resolution”. X-ray diffraction, 2 ligands (MG, CL), 5 pockets (best druggability 0.76). MolNFT v1 #108220 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4V07
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: UL26
EC: 3.4.21.97
UniProt: Q83417
Ligands: MG, CL
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	UL26 (EC 3.4.21.97)	protein	218	36% helix, 22% strand	Q83417
B	UL26 (EC 3.4.21.97)	protein	224	33% helix, 21% strand	Q83417

Ligands and binding sites

MG · Magnesium ion · metal · chains A
CL · Chloride ion · ion · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.76	0.97	23	empty
2	70	0.34	0.76	16	empty
3	54	0.34	0.78	14	CL
4	60	0.32	0.76	14	CL
5	57	0.26	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 1337 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

4V07 · Dimeric pseudorabies virus protease pUL26N at 2.1 A resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q83417
Elsewhere: RCSB PDB 4V07 · PDBe 4V07 · UniProt Q83417

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