MolNFT v1 · #108191 · protein + DNA
Kshv lana (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)
4UZB · Orf 73: “Kshv lana (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E…”. X-ray diffraction, 4 pockets (best druggability 0.67). MolNFT v1 #108191 on GenesisL1: 3D structure, binding…
- PDB
- 4UZB
- Type
- protein + DNA
- Length
- 314 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orf 73; Lana binding site 1 DNA
- UniProt
- Q76SB0
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Orf 73 | protein | 137 | 35% helix, 20% strand | Q76SB0 |
| C | Lana binding site 1 DNA | dna | 20 | — | — |
| D | Lana binding site 1 DNA | dna | 20 | — | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 385 | 0.67 | 0.80 | 50 | empty |
| 2 | 361 | 0.58 | 0.76 | 35 | empty |
| 3 | 164 | 0.40 | 0.73 | 23 | empty |
| 4 | 99 | 0.35 | 0.74 | 16 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2068 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 971 Ų buried · 93 hydrogen bonds · nucleic-nucleic
- A–C · 720 Ų buried · 11 hydrogen bonds · protein-nucleic
- A–D · 447 Ų buried · 5 hydrogen bonds · protein-nucleic
- B–C · 391 Ų buried · 9 hydrogen bonds · protein-nucleic
Compared structures
- 4UZB · KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q76SB0
- Elsewhere: RCSB PDB 4UZB · PDBe 4UZB · UniProt Q76SB0
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