MolNFT v1 · #108130 · protein

Crystal structure of the carboxy-terminal region of the bacteriophage T4 proximal long tail fibre protein GP34, R32 native crystal

4UXG · Large tail fiber protein P34: “Crystal structure of the carboxy-terminal region of the bacteriophage T4 proximal long tail fibre protein…”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #108130 on GenesisL1: 3D…

PDB: 4UXG
Type: protein
Length: 4,740 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Large tail fiber protein P34
UniProt: P18771
Pockets: 20 · best druggability 0.82

Structure

x-ray diffraction · 7 distinct chains · 2% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, G, L	Large tail fiber protein P34	protein	395	2% helix, 49% strand	P18771
C, E	Large tail fiber protein P34	protein	398	2% helix, 48% strand	P18771
D	Large tail fiber protein P34	protein	395	2% helix, 49% strand	P18771
F	Large tail fiber protein P34	protein	396	2% helix, 48% strand	P18771
H	Large tail fiber protein P34	protein	394	2% helix, 49% strand	P18771
I, J	Large tail fiber protein P34	protein	394	2% helix, 49% strand	P18771
K	Large tail fiber protein P34	protein	391	3% helix, 49% strand	P18771

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	164	0.82	0.97	31	empty
2	170	0.82	0.97	30	empty
3	159	0.82	0.97	32	empty
4	152	0.81	0.97	32	empty
5	89	0.79	0.98	20	empty

Interfaces

22 interfaces between chains.

B–C · 8962 Å² buried · 175 hydrogen bonds · protein-protein
E–F · 8945 Å² buried · 167 hydrogen bonds · protein-protein
D–E · 8937 Å² buried · 164 hydrogen bonds · protein-protein
K–L · 8927 Å² buried · 167 hydrogen bonds · protein-protein
G–H · 8926 Å² buried · 166 hydrogen bonds · protein-protein

Compared structures

4UXG · Crystal structure of the carboxy-terminal region of the bacteriophage T4 proximal long… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P18771
Elsewhere: RCSB PDB 4UXG · PDBe 4UXG · UniProt P18771

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