MolNFT v1 · #10809 · protein
Tetrameric structure of aldolase from thermus thermophilus HB8
1J2W · Aldolase protein: “Tetrameric structure of aldolase from thermus thermophilus HB8”. X-ray diffraction, 11 pockets (best druggability 0.59). MolNFT v1 #10809 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1J2W
- Type
- protein
- Length
- 845 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aldolase protein
- UniProt
- Q7SIC8
- Pockets
- 11 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 47% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Aldolase protein | protein | 212 | 47% helix, 17% strand | Q7SIC8 |
| B | Aldolase protein | protein | 211 | 47% helix, 17% strand | Q7SIC8 |
| D | Aldolase protein | protein | 210 | 47% helix, 17% strand | Q7SIC8 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 234 | 0.59 | 0.80 | 36 | empty |
| 2 | 125 | 0.57 | 0.84 | 25 | empty |
| 3 | 159 | 0.48 | 0.78 | 19 | empty |
| 4 | 103 | 0.47 | 0.80 | 21 | empty |
| 5 | 116 | 0.47 | 0.79 | 21 | empty |
Interfaces
6 interfaces between chains.
- A–C · 1566 Ų buried · 21 hydrogen bonds · protein-protein
- B–D · 1554 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 522 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 496 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 105 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1J2W · Tetrameric Structure of aldolase from Thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7SIC8
- Elsewhere: RCSB PDB 1J2W · PDBe 1J2W · UniProt Q7SIC8
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