MolNFT v1 · #108051 · protein

Crystal structure of anti-fpr FPRO0165 Fab fragment

4UV4: “Crystal structure of anti-fpr FPRO0165 Fab fragment”. X-ray diffraction, 4 pockets (best druggability 0.61). MolNFT v1 #108051 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4UV4
Type: protein
Length: 446 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: FPRO0165 Fab
Pockets: 4 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	FPRO0165 Fab	protein	229	8% helix, 54% strand	—
L	FPRO0165 Fab	protein	217	6% helix, 49% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	570	0.61	0.74	62	empty
2	100	0.40	0.76	20	empty
3	67	0.33	0.76	15	empty
4	58	0.27	0.73	16	empty

Interfaces

1 interface between chains.

H–L · 1751 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4UV4 · Crystal structure of anti-FPR Fpro0165 Fab fragment · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4UV4 · PDBe 4UV4

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