MolNFT v1 · #108049 · protein

Structure of the curli transport lipoprotein csgg in a non- lipidated, pre-pore conformation

4UV2 · Curli production transport component csgg: “Structure of the curli transport lipoprotein csgg in a non- lipidated, pre-pore conformation”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #108049 on GenesisL1: 3D…

PDB: 4UV2
Type: protein
Length: 3,700 residues
Chains: 16
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Curli production transport component csgg
UniProt: P0AEA2
Pockets: 20 · best druggability 0.75

Structure

x-ray diffraction · 12 distinct chains · 33% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Curli production transport component csgg	protein	234	34% helix, 33% strand	P0AEA2
B, H	Curli production transport component csgg	protein	236	33% helix, 33% strand	P0AEA2
D	Curli production transport component csgg	protein	235	34% helix, 33% strand	P0AEA2
E	Curli production transport component csgg	protein	241	35% helix, 32% strand	P0AEA2
F, K, L	Curli production transport component csgg	protein	234	33% helix, 33% strand	P0AEA2
G	Curli production transport component csgg	protein	235	33% helix, 33% strand	P0AEA2
I	Curli production transport component csgg	protein	235	34% helix, 33% strand	P0AEA2
J	Curli production transport component csgg	protein	228	33% helix, 33% strand	P0AEA2
M	Curli production transport component csgg	protein	217	33% helix, 33% strand	P0AEA2
N	Curli production transport component csgg	protein	233	33% helix, 33% strand	P0AEA2
O	Curli production transport component csgg	protein	218	33% helix, 33% strand	P0AEA2
P	Curli production transport component csgg	protein	216	33% helix, 32% strand	P0AEA2

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	714	0.75	0.80	64	empty
2	708	0.74	0.80	64	empty
3	298	0.73	0.86	57	empty
4	480	0.69	0.80	61	empty
5	397	0.69	0.81	73	empty

Interfaces

24 interfaces between chains.

D–E · 2090 Å² buried · 38 hydrogen bonds · protein-protein
L–M · 2065 Å² buried · 35 hydrogen bonds · protein-protein
I–J · 2060 Å² buried · 32 hydrogen bonds · protein-protein
A–H · 2055 Å² buried · 39 hydrogen bonds · protein-protein
B–C · 2044 Å² buried · 39 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 80 modified (engineered).

Compared structures

4UV2 · Structure of the curli transport lipoprotein CsgG in a non-lipidated, pre-pore… · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AEA2
Elsewhere: RCSB PDB 4UV2 · PDBe 4UV2 · UniProt P0AEA2

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