MolNFT v1 · #108033 · protein
Apo trichomonas vaginalis lactate dehydrogenase L91R
4UUL · L-lactate dehydrogenase: “Apo trichomonas vaginalis lactate dehydrogenase L91R”. X-ray diffraction, 8 pockets (best druggability 0.67). MolNFT v1 #108033 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4UUL
- Type
- protein
- Length
- 671 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-lactate dehydrogenase
- EC
- 1.1.1.27
- UniProt
- O96445
- Pockets
- 8 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-lactate dehydrogenase (EC 1.1.1.27) | protein | 334 | 47% helix, 19% strand | O96445 |
| B | L-lactate dehydrogenase (EC 1.1.1.27) | protein | 337 | 48% helix, 19% strand | O96445 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 614 | 0.67 | 0.77 | 58 | empty |
| 2 | 499 | 0.65 | 0.77 | 42 | empty |
| 3 | 414 | 0.63 | 0.77 | 42 | empty |
| 4 | 316 | 0.61 | 0.78 | 35 | empty |
| 5 | 134 | 0.47 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1671 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 4UUL · Apo trichomonas vaginalis lactate dehydrogenase L91R · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O96445
- Elsewhere: RCSB PDB 4UUL · PDBe 4UUL · UniProt O96445
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