MolNFT v1 · #10803 · protein

Alpha-ring from the proteasome from archaeoglobus fulgidus

1J2P · Proteasome alpha subunit: “Alpha-ring from the proteasome from archaeoglobus fulgidus”. X-ray diffraction, 11 pockets (best druggability 0.74). MolNFT v1 #10803 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1J2P
Type: protein
Length: 1,701 residues
Chains: 7
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proteasome alpha subunit
EC: 3.4.25.1
UniProt: O29760
Pockets: 11 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Proteasome alpha subunit (EC 3.4.25.1)	protein	243	40% helix, 23% strand	O29760

Pockets

11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	700	0.74	0.80	61	empty
2	730	0.74	0.79	58	empty
3	694	0.74	0.80	57	empty
4	666	0.74	0.80	56	empty
5	749	0.73	0.79	61	empty

Interfaces

7 interfaces between chains.

E–F · 1475 Å² buried · 31 hydrogen bonds · protein-protein
D–E · 1461 Å² buried · 28 hydrogen bonds · protein-protein
B–C · 1437 Å² buried · 29 hydrogen bonds · protein-protein
A–G · 1435 Å² buried · 26 hydrogen bonds · protein-protein
F–G · 1411 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

1J2P · alpha-ring from the proteasome from archaeoglobus fulgidus · the same entry in another collection · chain G against G, TM-score 1.00
O29760 · AlphaFold monomer V2.0 prediction for proteasome subunit alpha (O29760) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O29760
Elsewhere: RCSB PDB 1J2P · PDBe 1J2P · UniProt O29760

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