MolNFT v1 · #107912 · protein

Coevolution of the ATPase clpv, the tssb-tssc sheath and the accessory hsie protein distinguishes two type VI secretion classes

4UQX · HSIE1: “Coevolution of the ATPase clpv, the tssb-tssc sheath and the accessory hsie protein distinguishes two type VI…”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #107912 on GenesisL1: 3D structure, binding…

PDB: 4UQX
Type: protein
Length: 262 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HSIE1
UniProt: Q9I746
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	HSIE1	protein	262	44% helix, 24% strand	Q9I746

Ligands and binding sites

MPD · (4S)-2-methyl-2,4-pentanediol · additive · 2 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.45	0.80	20	ACT

Compared structures

4UQX · Coevolution of the ATPase ClpV, the TssB-TssC Sheath and the Accessory HsiE Protein… · the same entry in another collection · chain A against A, TM-score 1.00
Q9I746 · AlphaFold monomer V2.0 prediction for type VI secretion system accessory component tagj… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I746
Elsewhere: RCSB PDB 4UQX · PDBe 4UQX · UniProt Q9I746

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