MolNFT v1 · #107717 · protein
Cryo-EM structure of dengue virus serotype 2 strain new guinea-C complexed with human antibody 2D22 Fab at 37 degree C. the Fab molecules were added to the virus before 37 degree C incubation.
4UIH · Dengue virus serotype 2 strain new guinea-C E protein…: “Cryo-EM structure of dengue virus serotype 2 strain new guinea-C complexed with human antibody 2D22 Fab at 37…”. Electron microscopy, 1 pocket (best druggability 0.36). MolNFT…
- PDB
- 4UIH
- Type
- protein
- Length
- 1,647 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dengue virus serotype 2 strain new guinea-C E protein ectodomain; Antigen-binding…
- EC
- 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48
- UniProt
- P14340
- Pockets
- 1 · best druggability 0.36
Structure
electron microscopy · 3 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Dengue virus serotype 2 strain new guinea-C E protein ectodomain (EC 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48) | protein | 395 | 0% helix, 0% strand | P14340 |
| D, F | Antigen-binding fragment of human antibody 2D22 -heavy chain | protein | 120 | 0% helix, 0% strand | — |
| E, G | Antigen-binding fragment of human antibody 2D22 -light chain | protein | 111 | 0% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.36 | 0.73 | 31 | empty |
Interfaces
8 interfaces between chains.
- A–C · 231 Ų buried · 0 hydrogen bonds · protein-protein
- C–F · 155 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 135 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 134 Ų buried · 0 hydrogen bonds · protein-protein
- D–E · 59 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4UIH · Cryo-EM structure of Dengue virus serotype 2 strain New Guinea-C complexed with human… · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14340
- Elsewhere: RCSB PDB 4UIH · PDBe 4UIH · UniProt P14340
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.