MolNFT v1 · #107715 · protein
Cryo-EM structure of dengue virus serotype 2 in complex with antigen- binding fragments of human antibody 2D22
4UIF · Dengue virus serotype 2 strain PVP94 07 - envelope protein: “Cryo-EM structure of dengue virus serotype 2 in complex with antigen- binding fragments of human antibody 2D22”. Electron microscopy, 4 pockets (best druggability 0.43).…
- PDB
- 4UIF
- Type
- protein
- Length
- 2,394 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dengue virus serotype 2 strain PVP94 07 - envelope protein; Dengue virus serotype 2…
- UniProt
- D6MQ38, E0WXJ3, S6BGD6
- Pockets
- 4 · best druggability 0.43
Structure
electron microscopy · 4 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Dengue virus serotype 2 strain PVP94 07 - envelope protein | protein | 495 | 0% helix, 0% strand | D6MQ38 |
| B, D, F | Dengue virus serotype 2 strain strain PVP94 07 - membrane protein | protein | 72 | 0% helix, 0% strand | E0WXJ3 |
| G, I, K | Antigen-binding fragment of human antibody 2D22 - heavy chain | protein | 120 | 0% helix, 0% strand | — |
| H, J, L | Antigen-binding fragment of human antibody 2D22 - light chain | protein | 111 | 0% helix, 0% strand | S6BGD6 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.43 | 0.73 | 38 | empty |
| 2 | 115 | 0.39 | 0.73 | 32 | empty |
| 3 | 110 | 0.38 | 0.73 | 29 | empty |
| 4 | 82 | 0.33 | 0.72 | 31 | empty |
Interfaces
15 interfaces between chains.
- E–F · 304 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 269 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 246 Ų buried · 0 hydrogen bonds · protein-protein
- C–E · 229 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 218 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4UIF · Cryo-EM structure of Dengue virus serotype 2 in complex with antigen-binding fragments of… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D6MQ38
- Every structure of UniProt E0WXJ3
- Every structure of UniProt S6BGD6
- Elsewhere: RCSB PDB 4UIF · PDBe 4UIF · UniProt D6MQ38 · UniProt E0WXJ3 · UniProt S6BGD6
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