MolNFT v1 · #107694 · protein

W229D mutant of the last common ancestor of gram-negative bacteria (gnca) beta-lactamase class a

4UHU · Gnca lactamase W229D: “W229D mutant of the last common ancestor of gram-negative bacteria (gnca) beta-lactamase class a”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #107694 on GenesisL1: 3D structure, binding…

PDB: 4UHU
Type: protein
Length: 264 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gnca lactamase W229D
EC: 3.5.2.6
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gnca lactamase W229D (EC 3.5.2.6)	protein	264	44% helix, 18% strand	—

Ligands and binding sites

FMT · Formic acid · additive · 3 copies · chains A
ACT · Acetate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.30	0.73	17	ACT

Compared structures

4UHU · W229D mutant of the last common ancestor of Gram-negative bacteria (GNCA) beta-lactamase… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4UHU · PDBe 4UHU

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