MolNFT v1 · #107692 · protein
Crystal structure of the receiver domain of cpxr from E. COLI (tetragonal form)
4UHS · Transcriptional regulatory protein cpxr: “Crystal structure of the receiver domain of cpxr from E. COLI (tetragonal form)”. X-ray diffraction, 1 ligand (MG), 3 pockets (best druggability 0.71). MolNFT v1 #107692 on GenesisL1: 3D…
- PDB
- 4UHS
- Type
- protein
- Length
- 378 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulatory protein cpxr
- UniProt
- P0AE88
- Ligands
- MG
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Transcriptional regulatory protein cpxr | protein | 126 | 48% helix, 18% strand | P0AE88 |
Ligands and binding sites
- MG · Magnesium ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 686 | 0.71 | 0.78 | 77 | empty |
| 2 | 112 | 0.42 | 0.77 | 20 | empty |
| 3 | 62 | 0.31 | 0.76 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1482 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 310 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 272 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4UHS · Crystal structure of the receiver domain of CpxR from E. coli (tetragonal form) · the same entry in another collection · chain A against A, TM-score 1.00
- P0AE88 · AlphaFold monomer V2.0 prediction for transcriptional regulatory protein cpxr (P0AE88) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AE88
- Elsewhere: RCSB PDB 4UHS · PDBe 4UHS · UniProt P0AE88
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.