MolNFT v1 · #107688 · protein
Characterization of a novel transaminase from pseudomonas sp. strain aac
4UHO · Omega amino acid-pyruvate aminotransferase: “Characterization of a novel transaminase from pseudomonas sp. strain aac”. X-ray diffraction, 3 ligands (UNL, PLP, MG), 3 pockets (best druggability 0.70). MolNFT v1 #107688 on GenesisL1…
- PDB
- 4UHO
- Type
- protein
- Length
- 435 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Omega amino acid-pyruvate aminotransferase
- EC
- 2.6.1.18
- UniProt
- A0A081YAY5
- Ligands
- UNL, PLP, MG
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Omega amino acid-pyruvate aminotransferase (EC 2.6.1.18) | protein | 435 | 40% helix, 18% strand | A0A081YAY5 |
Ligands and binding sites
- UNL · Unknown ligand · ligand · chains A
- PLP · Pyridoxal-5'-phosphate · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- GOL · Glycerol · additive · 5 copies · chains A
- EDO · 1,2-ethanediol · additive · 4 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
- EOH · Ethanol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 736 | 0.70 | 0.77 | 67 | GOL, PLP |
| 2 | 427 | 0.67 | 0.79 | 35 | empty |
| 3 | 52 | 0.63 | 0.94 | 18 | empty |
Compared structures
- 4UHO · Characterization of a Novel Transaminase from Pseudomonas sp. Strain AAC · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A081YAY5
- Elsewhere: RCSB PDB 4UHO · PDBe 4UHO · UniProt A0A081YAY5
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