MolNFT v1 · #10758 · protein
Crystal structure of the radxin ferm domain complexed with the icam-2 cytoplasmic peptide
1J19 · Radixin: “Crystal structure of the radxin ferm domain complexed with the icam-2 cytoplasmic peptide”. X-ray diffraction, 4 pockets (best druggability 0.70). MolNFT v1 #10758 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1J19
- Type
- protein
- Length
- 332 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Radixin; 16-mer peptide from intercellular adhesion molecule-2
- UniProt
- P26043, P35330
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Radixin | protein | 316 | 37% helix, 22% strand | P26043 |
| B | 16-mer peptide from intercellular adhesion molecule-2 | protein | 16 | 19% helix, 25% strand | P35330 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 584 | 0.70 | 0.78 | 50 | empty |
| 2 | 64 | 0.42 | 0.80 | 24 | empty |
| 3 | 71 | 0.34 | 0.76 | 15 | empty |
| 4 | 98 | 0.33 | 0.73 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 648 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 1J19 · Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P26043 · AlphaFold monomer V2.0 prediction for radixin (P26043) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P35330 · AlphaFold monomer V2.0 prediction for intercellular adhesion molecule 2 (P35330) · a predicted model of the same protein · chain B against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26043
- Every structure of UniProt P35330
- Elsewhere: RCSB PDB 1J19 · PDBe 1J19 · UniProt P26043 · UniProt P35330
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