MolNFT v1 · #107534 · protein
Structural plasticity of CID1 provides a basis for its RNA terminal uridylyl transferase activity
4UD4 · POLY(A) RNA polymerase protein CID1: “Structural plasticity of CID1 provides a basis for its RNA terminal uridylyl transferase activity”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #107534 on GenesisL1: 3D…
- PDB
- 4UD4
- Type
- protein
- Length
- 641 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POLY(A) RNA polymerase protein CID1
- EC
- 2.7.7.-
- UniProt
- O13833
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | POLY(A) RNA polymerase protein CID1 (EC 2.7.7.-) | protein | 324 | 46% helix, 13% strand | O13833 |
| B | POLY(A) RNA polymerase protein CID1 (EC 2.7.7.-) | protein | 317 | 46% helix, 13% strand | O13833 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 327 | 0.78 | 0.89 | 48 | empty |
| 2 | 561 | 0.63 | 0.75 | 62 | empty |
| 3 | 257 | 0.54 | 0.76 | 38 | empty |
| 4 | 60 | 0.42 | 0.81 | 11 | empty |
| 5 | 82 | 0.31 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 403 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4UD4 · Structural Plasticity of Cid1 Provides a Basis for its RNA Terminal Uridylyl Transferase… · the same entry in another collection · chain A against A, TM-score 1.00
- O13833 · AlphaFold monomer V2.0 prediction for terminal uridylyltransferase CID1 (O13833) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13833
- Elsewhere: RCSB PDB 4UD4 · PDBe 4UD4 · UniProt O13833
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