MolNFT v1 · #107531 · protein
X-ray structure and activities of an essential mononegavirales L- protein domain
4UD0 · RNA-directed RNA polymerase L: “X-ray structure and activities of an essential mononegavirales L- protein domain”. X-ray diffraction, 3 ligands (SAH, ZN, SO4), 2 pockets (best druggability 0.66). MolNFT v1 #107531 on GenesisL1: 3D…
- PDB
- 4UD0
- Type
- protein
- Length
- 350 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L
- UniProt
- Q91L20
- Ligands
- SAH, ZN, SO4
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | RNA-directed RNA polymerase L | protein | 350 | 41% helix, 13% strand | Q91L20 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains B
- ZN · Zinc ion · metal · chains B
- SO4 · Sulfate ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 514 | 0.66 | 0.78 | 60 | SO4, SAH |
| 2 | 76 | 0.51 | 0.84 | 16 | empty |
Compared structures
- 4UD0 · X-ray structure and activities of an essential Mo gavirales L- protein domain · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q91L20
- Elsewhere: RCSB PDB 4UD0 · PDBe 4UD0 · UniProt Q91L20
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