MolNFT v1 · #107503 · protein
N-terminal globular domain of the rsv nucleoprotein in complex with C-terminal phenylalanine of the phosphoprotein
4UC8: “N-terminal globular domain of the rsv nucleoprotein in complex with C-terminal phenylalanine of the…”. X-ray diffraction, 2 ligands (PHE, SO4), 3 pockets (best druggability 0.44). MolNFT v1 #107503 on GenesisL1: 3D structure…
- PDB
- 4UC8
- Type
- protein
- Length
- 444 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein
- UniProt
- P03418
- Ligands
- PHE, SO4
- Pockets
- 3 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoprotein | protein | 222 | 60% helix, 9% strand | P03418 |
| B | Nucleoprotein | protein | 222 | 61% helix, 10% strand | P03418 |
Ligands and binding sites
- PHE · Phenylalanine · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 8 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 202 | 0.44 | 0.73 | 31 | empty |
| 2 | 116 | 0.42 | 0.76 | 23 | empty |
| 3 | 84 | 0.35 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 161 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4UC8 · N-terminal globular domain of the RSV Nucleoprotein in complex with C- terminal… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03418
- Elsewhere: RCSB PDB 4UC8 · PDBe 4UC8 · UniProt P03418
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