MolNFT v1 · #107320 · protein

Crystal structure of the COG5-COG7 complex from kluyveromyces lactis

4U6U: “Crystal structure of the COG5-COG7 complex from kluyveromyces lactis”. X-ray diffraction, 2 pockets (best druggability 0.73). MolNFT v1 #107320 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4U6U
Type: protein
Length: 699 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: COG7; COG5
UniProt: Q6CXE9, Q6CLE2
Pockets: 2 · best druggability 0.73

Structure

x-ray diffraction · 3 distinct chains · 77% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	COG7	protein	67	69% helix, 0% strand	Q6CXE9
B	COG5	protein	282	76% helix, 1% strand	Q6CLE2
D	COG5	protein	283	80% helix, 1% strand	Q6CLE2

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.73	0.95	21	empty
2	72	0.32	0.74	11	empty

Interfaces

5 interfaces between chains.

C–D · 1580 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 1563 Å² buried · 11 hydrogen bonds · protein-protein
A–C · 578 Å² buried · 11 hydrogen bonds · protein-protein
A–D · 88 Å² buried · 2 hydrogen bonds · protein-protein
B–C · 71 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4U6U · Crystal Structure of the Cog5-Cog7 complex from Kluyveromyces lactis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6CXE9
Every structure of UniProt Q6CLE2
Elsewhere: RCSB PDB 4U6U · PDBe 4U6U · UniProt Q6CXE9 · UniProt Q6CLE2

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