MolNFT v1 · #107314 · protein

Structure of the cap-binding domain of influenza virus polymerase subunit PB2

4U6O · Polymerase basic protein 2: “Structure of the cap-binding domain of influenza virus polymerase subunit PB2”. X-ray diffraction, 1 ligand (PO4), 3 pockets (best druggability 0.75). MolNFT v1 #107314 on GenesisL1: 3D structure…

PDB: 4U6O
Type: protein
Length: 322 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase basic protein 2
UniProt: P03428
Ligands: PO4
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase basic protein 2	protein	166	22% helix, 39% strand	P03428
B	Polymerase basic protein 2	protein	156	24% helix, 42% strand	P03428

Ligands and binding sites

PO4 · Phosphate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	644	0.75	0.81	56	PO4
2	89	0.39	0.76	14	PO4
3	79	0.36	0.76	23	empty

Interfaces

1 interface between chains.

A–B · 700 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

4U6O · Structure of the cap-binding domain of influenza virus polymerase subunit PB2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03428
Elsewhere: RCSB PDB 4U6O · PDBe 4U6O · UniProt P03428

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.