MolNFT v1 · #107188 · protein

N-terminal domain of C. reinhardtii sas-6 homolog BLD12P variant Q93E F145W (NN27)

4U2J · Centriole protein: “N-terminal domain of C. reinhardtii sas-6 homolog BLD12P variant Q93E F145W (NN27)”. X-ray diffraction, 2 pockets (best druggability 0.76). MolNFT v1 #107188 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 4U2J
Type: protein
Length: 564 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Centriole protein
UniProt: A9CQL4
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 21% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D, B	Centriole protein	protein	142	22% helix, 57% strand	A9CQL4
C	Centriole protein	protein	138	20% helix, 57% strand	A9CQL4

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1037	0.76	0.78	94	empty
2	163	0.40	0.73	21	empty

Interfaces

5 interfaces between chains.

C–D · 827 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 805 Å² buried · 9 hydrogen bonds · protein-protein
A–D · 488 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 353 Å² buried · 6 hydrogen bonds · protein-protein
C–B · 132 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4U2J · N-terminal domain of C. Reinhardtii SAS-6 homolog bld12p variant Q93E F145W (NN27) · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9CQL4
Elsewhere: RCSB PDB 4U2J · PDBe 4U2J · UniProt A9CQL4

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