MolNFT v1 · #107156 · protein
Crystal structure of middle domain of eukaryotic translation initiation factor EIF3B
4U1F · Eukaryotic translation initiation factor 3 subunit B: “Crystal structure of middle domain of eukaryotic translation initiation factor EIF3B”. X-ray diffraction, 8 pockets (best druggability 0.61). MolNFT v1 #107156 on GenesisL1: 3D…
- PDB
- 4U1F
- Type
- protein
- Length
- 949 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit B
- UniProt
- P06103
- Pockets
- 8 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 3 subunit B | protein | 474 | 4% helix, 45% strand | P06103 |
| B | Eukaryotic translation initiation factor 3 subunit B | protein | 475 | 4% helix, 46% strand | P06103 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 627 | 0.61 | 0.73 | 66 | empty |
| 2 | 598 | 0.61 | 0.73 | 61 | empty |
| 3 | 240 | 0.57 | 0.79 | 34 | empty |
| 4 | 117 | 0.45 | 0.78 | 20 | empty |
| 5 | 117 | 0.44 | 0.77 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 3798 Ų buried · 58 hydrogen bonds · protein-protein
Compared structures
- 4U1F · Crystal structure of middle domain of eukaryotic translation initiation factor eIF3b · the same entry in another collection · chain A against A, TM-score 1.00
- P06103 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06103
- Elsewhere: RCSB PDB 4U1F · PDBe 4U1F · UniProt P06103
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