MolNFT v1 · #107133 · protein
Plasmodium falciparum reticulocyte-binding protein homologue 5 (PFRH5) bound to monoclonal antibody 9AD4
4U0R · Reticulocyte binding protein 5: “Plasmodium falciparum reticulocyte-binding protein homologue 5 (PFRH5) bound to monoclonal antibody 9AD4”. X-ray diffraction, 9 pockets (best druggability 0.57). MolNFT v1 #107133 on GenesisL1: 3D…
- PDB
- 4U0R
- Type
- protein
- Length
- 726 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reticulocyte binding protein 5; Monoclonal antibody 9AD4 heavy chain; Monoclonal antibody…
- UniProt
- B2L3N7
- Pockets
- 9 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Reticulocyte binding protein 5 | protein | 288 | 79% helix, 3% strand | B2L3N7 |
| B | Monoclonal antibody 9AD4 heavy chain | protein | 221 | 8% helix, 54% strand | — |
| C | Monoclonal antibody 9AD4 light chain | protein | 217 | 6% helix, 53% strand | — |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 374 | 0.57 | 0.75 | 47 | empty |
| 2 | 112 | 0.55 | 0.83 | 20 | empty |
| 3 | 175 | 0.52 | 0.78 | 26 | empty |
| 4 | 103 | 0.50 | 0.81 | 18 | empty |
| 5 | 138 | 0.45 | 0.77 | 20 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1966 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 635 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 229 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4U0R · Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B2L3N7
- Elsewhere: RCSB PDB 4U0R · PDBe 4U0R · UniProt B2L3N7
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