MolNFT v1 · #107088 · protein

Structure of unliganded lyn SH2 domain

4TZI · Tyrosine-protein kinase lyn: “Structure of unliganded lyn SH2 domain”. X-ray diffraction, 1 pocket (best druggability 0.44). MolNFT v1 #107088 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4TZI
Type: protein
Length: 218 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase lyn
EC: 2.7.10.2
UniProt: P25911
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase lyn (EC 2.7.10.2)	protein	110	16% helix, 29% strand	P25911
B	Tyrosine-protein kinase lyn (EC 2.7.10.2)	protein	108	20% helix, 27% strand	P25911

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	123	0.44	0.77	19	empty

Interfaces

1 interface between chains.

A–B · 195 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4TZI · Structure of unliganded Lyn SH2 domain · the same entry in another collection · chain A against A, TM-score 1.00
P25911 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase lyn (P25911) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25911
Elsewhere: RCSB PDB 4TZI · PDBe 4TZI · UniProt P25911

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