MolNFT v1 · #106840 · protein

Crystal structure of monoclonal antibody against neuroblastoma associated antigen.

4TRP · Heavy chain of monoclonal antibody against neuroblastoma…: “Crystal structure of monoclonal antibody against neuroblastoma associated antigen.”. X-ray diffraction, 5 pockets (best druggability 0.57). MolNFT v1 #106840 on GenesisL1…

PDB: 4TRP
Type: protein
Length: 422 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heavy chain of monoclonal antibody against neuroblastoma associated antigen; Light chain…
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Heavy chain of monoclonal antibody against neuroblastoma associated antigen	protein	203	8% helix, 53% strand	—
L	Light chain of monoclonal antibody against neuroblastoma associated antigen	protein	219	5% helix, 53% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	414	0.57	0.74	50	empty
2	120	0.41	0.75	27	empty
3	116	0.38	0.74	24	empty
4	65	0.34	0.76	17	empty
5	55	0.27	0.74	12	empty

Interfaces

1 interface between chains.

H–L · 1739 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4TRP · Crystal structure of monoclonal antibody against neuroblastoma associated antigen. · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4TRP · PDBe 4TRP

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