MolNFT v1 · #106823 · protein
Crystal structure of DNA polymerase sliding clamp from mycobaterium tuberculosis
4TR7 · DNA polymerase III subunit beta: “Crystal structure of DNA polymerase sliding clamp from mycobaterium tuberculosis”. X-ray diffraction, 8 pockets (best druggability 0.53). MolNFT v1 #106823 on GenesisL1: 3D structure, binding sites…
- PDB
- 4TR7
- Type
- protein
- Length
- 745 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase III subunit beta
- EC
- 2.7.7.7
- UniProt
- P9WNU0
- Pockets
- 8 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA polymerase III subunit beta (EC 2.7.7.7) | protein | 375 | 21% helix, 43% strand | P9WNU0 |
| B | DNA polymerase III subunit beta (EC 2.7.7.7) | protein | 370 | 23% helix, 44% strand | P9WNU0 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.53 | 0.85 | 16 | empty |
| 2 | 73 | 0.53 | 0.86 | 19 | empty |
| 3 | 129 | 0.50 | 0.80 | 23 | empty |
| 4 | 65 | 0.50 | 0.85 | 16 | empty |
| 5 | 87 | 0.48 | 0.81 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1188 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 4TR7 · Crystal structure of DNA polymerase sliding clamp from Mycobaterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
- P9WNU0 · AlphaFold monomer V2.0 prediction for beta sliding clamp (P9WNU0) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WNU0
- Elsewhere: RCSB PDB 4TR7 · PDBe 4TR7 · UniProt P9WNU0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.