MolNFT v1 · #106782 · protein
N-terminal domain of C. reinhardtii sas-6 homolog BLD12P F145W (NN2)
4TPZ · Centriole protein: “N-terminal domain of C. reinhardtii sas-6 homolog BLD12P F145W (NN2)”. X-ray diffraction, 2 pockets (best druggability 0.71). MolNFT v1 #106782 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4TPZ
- Type
- protein
- Length
- 570 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centriole protein
- UniProt
- A9CQL4
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 20% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Centriole protein | protein | 145 | 21% helix, 58% strand | A9CQL4 |
| B | Centriole protein | protein | 143 | 20% helix, 56% strand | A9CQL4 |
| C | Centriole protein | protein | 138 | 20% helix, 55% strand | A9CQL4 |
| D | Centriole protein | protein | 144 | 19% helix, 50% strand | A9CQL4 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1194 | 0.71 | 0.75 | 98 | empty |
| 2 | 683 | 0.65 | 0.75 | 58 | empty |
Interfaces
5 interfaces between chains.
- B–C · 821 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 816 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 459 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 389 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 86 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4TPZ · N-terminal domain of C. Reinhardtii SAS-6 homolog bld12p F145W (NN2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A9CQL4
- Elsewhere: RCSB PDB 4TPZ · PDBe 4TPZ · UniProt A9CQL4
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