MolNFT v1 · #106673 · protein

Cards toxin, full-length

4TLW · ADP-ribosylating toxin cards: “Cards toxin, full-length”. X-ray diffraction, 6 pockets (best druggability 0.68). MolNFT v1 #106673 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4TLW
Type: protein
Length: 567 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ADP-ribosylating toxin cards
EC: 2.4.2.-
UniProt: P75409
Pockets: 6 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ADP-ribosylating toxin cards (EC 2.4.2.-)	protein	567	14% helix, 37% strand	P75409

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	548	0.68	0.78	48	empty
2	60	0.63	0.93	26	empty
3	169	0.61	0.84	28	empty
4	136	0.49	0.79	26	empty
5	99	0.37	0.75	25	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4TLW · Cards toxin, full-length · the same entry in another collection · chain A against A, TM-score 1.00
P75409 · AlphaFold monomer V2.0 prediction for ADP-ribosylating toxin cards (P75409) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P75409
Elsewhere: RCSB PDB 4TLW · PDBe 4TLW · UniProt P75409

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