MolNFT v1 · #106662 · protein
Crystal structure of human transthyretin SER85PRO/GLU92PRO mutant
4TLK: “Crystal structure of human transthyretin SER85PRO/GLU92PRO mutant”. X-ray diffraction, 1 ligand (NA), 1 pocket (best druggability 0.36). MolNFT v1 #106662 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4TLK
- Type
- protein
- Length
- 230 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Ligands
- NA
- Pockets
- 1 · best druggability 0.36
Structure
x-ray diffraction · 1 distinct chain · 7% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transthyretin | protein | 115 | 7% helix, 53% strand | P02766 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains B, A
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.36 | 0.76 | 21 | PEG |
Interfaces
1 interface between chains.
- A–B · 936 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 4TLK · Crystal Structure of Human Transthyretin Ser85Pro/Glu92Pro Mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 4TLK · PDBe 4TLK · UniProt P02766
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