GCN4-P1 with mutation to 1-aminocyclohexanecarboxylic acid at residue 10

Structure

x-ray diffraction · 2 distinct chains · 92% helix, 0% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · 2 copies · chains A, B
• NH2 · Amino group · ion · chains A
• IPA · Isopropyl alcohol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 962 Ų buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent, 2 modified (covalent ligand, nonstandard).

Compared structures

• 4TL1 · GCN4-p1 with mutation to 1-Aminocyclohexanecarboxylic acid at residue 10 · the same entry in another collection · chain A against A, TM-score 1.00
• P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P03069
• Elsewhere: RCSB PDB 4TL1 · PDBe 4TL1 · UniProt P03069