MolNFT v1 · #106639 · protein

Crystal structure of human transthyretin LEU55PRO mutant

4TKW: “Crystal structure of human transthyretin LEU55PRO mutant”. X-ray diffraction, 2 pockets (best druggability 0.40). MolNFT v1 #106639 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4TKW
Type: protein
Length: 230 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transthyretin
UniProt: P02766
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transthyretin	protein	115	6% helix, 51% strand	P02766

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.40	0.76	19	empty
2	72	0.31	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 899 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

4TKW · Crystal Structure of Human Transthyretin Leu55Pro Mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02766
Elsewhere: RCSB PDB 4TKW · PDBe 4TKW · UniProt P02766

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.