MolNFT v1 · #106621 · protein

Sulfolobus solfataricus hjc mutants

4TKD · Holliday junction resolvase hjc: “Sulfolobus solfataricus hjc mutants”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #106621 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4TKD
Type: protein
Length: 477 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Holliday junction resolvase hjc
EC: 3.1.22.4
UniProt: Q7LXU0
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 4 distinct chains · 33% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Holliday junction resolvase hjc (EC 3.1.22.4)	protein	120	34% helix, 31% strand	Q7LXU0
B	Holliday junction resolvase hjc (EC 3.1.22.4)	protein	117	32% helix, 36% strand	Q7LXU0
C	Holliday junction resolvase hjc (EC 3.1.22.4)	protein	125	33% helix, 31% strand	Q7LXU0
D	Holliday junction resolvase hjc (EC 3.1.22.4)	protein	115	33% helix, 34% strand	Q7LXU0

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	159	0.43	0.74	30	empty
2	72	0.42	0.80	15	empty

Interfaces

3 interfaces between chains.

C–D · 813 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 767 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 707 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

4TKD · Sulfolobus solfataricus HJC mutants · the same entry in another collection · chain A against A, TM-score 1.00
Q7LXU0 · AlphaFold monomer V2.0 prediction for holliday junction resolvase hjc (Q7LXU0) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7LXU0
Elsewhere: RCSB PDB 4TKD · PDBe 4TKD · UniProt Q7LXU0

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