MolNFT v1 · #106558 · protein
Crystal structure of the phosphorybosylpyrophosphate synthetase from E. COLI
4S2U · Ribose-phosphate pyrophosphokinase: “Crystal structure of the phosphorybosylpyrophosphate synthetase from E. COLI”. X-ray diffraction, 1 ligand (MG), 3 pockets (best druggability 0.47). MolNFT v1 #106558 on GenesisL1: 3D structure…
- PDB
- 4S2U
- Type
- protein
- Length
- 308 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribose-phosphate pyrophosphokinase
- EC
- 2.7.6.1
- UniProt
- G4PTS0
- Ligands
- MG
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribose-phosphate pyrophosphokinase (EC 2.7.6.1) | protein | 308 | 32% helix, 22% strand | G4PTS0 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.47 | 0.77 | 30 | MG |
| 2 | 61 | 0.32 | 0.76 | 14 | empty |
| 3 | 57 | 0.29 | 0.74 | 21 | empty |
Compared structures
- 4S2U · Crystal structure of the Phosphorybosylpyrophosphate synthetase from E. Coli · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G4PTS0
- Elsewhere: RCSB PDB 4S2U · PDBe 4S2U · UniProt G4PTS0
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