MolNFT v1 · #106273 · protein
Human K2P4.1 (traak) potassium channel, G124I mutant
4RUE · Potassium channel subfamily K member 4: “Human K2P4.1 (traak) potassium channel, G124I mutant”. X-ray diffraction, 1 ligand (K), 8 pockets (best druggability 0.70). MolNFT v1 #106273 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4RUE
- Type
- protein
- Length
- 503 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium channel subfamily K member 4
- UniProt
- Q9NYG8
- Ligands
- K
- Pockets
- 8 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium channel subfamily K member 4 | protein | 251 | 66% helix, 0% strand | Q9NYG8 |
| B | Potassium channel subfamily K member 4 | protein | 252 | 72% helix, 0% strand | Q9NYG8 |
Ligands and binding sites
- K · Potassium ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 856 | 0.70 | 0.76 | 61 | K |
| 2 | 797 | 0.70 | 0.76 | 77 | K |
| 3 | 94 | 0.58 | 0.85 | 16 | empty |
| 4 | 142 | 0.46 | 0.77 | 18 | empty |
| 5 | 133 | 0.45 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 4715 Ų buried · 48 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4RUE · Human K2P4.1 (TRAAK) potassium channel, G124I mutant · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NYG8 · AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 4 (Q9NYG8) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NYG8
- Elsewhere: RCSB PDB 4RUE · PDBe 4RUE · UniProt Q9NYG8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.