MolNFT v1 · #106206 · protein
Structure of MYC3 N-terminal jaz-binding domain [44-238] in complex with jas motif of JAZ9
4RS9 · Transcription factor MYC3: “Structure of MYC3 N-terminal jaz-binding domain [44-238] in complex with jas motif of JAZ9”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #106206 on GenesisL1: 3D structure, binding…
- PDB
- 4RS9
- Type
- protein
- Length
- 190 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor MYC3; Protein tify 7
- UniProt
- Q9FIP9, Q8W4J8
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription factor MYC3 | protein | 171 | 41% helix, 27% strand | Q9FIP9 |
| B | Protein tify 7 | protein | 19 | 84% helix, 0% strand | Q8W4J8 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.43 | 0.82 | 16 | empty |
| 2 | 87 | 0.41 | 0.78 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 701 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4RS9 · Structure of Myc3 N-terminal JAZ-binding domain [44-238] in complex with Jas motif of JAZ9 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9FIP9 · AlphaFold monomer V2.0 prediction for transcription factor MYC3 (Q9FIP9) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q8W4J8 · AlphaFold monomer V2.0 prediction for protein tify 7 (Q8W4J8) · a predicted model of the same protein · chain B against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9FIP9
- Every structure of UniProt Q8W4J8
- Elsewhere: RCSB PDB 4RS9 · PDBe 4RS9 · UniProt Q9FIP9 · UniProt Q8W4J8
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