MolNFT v1 · #106076 · protein

2.8A resolution structure of SRPN2 (K198C) from anopheles gambiae

4ROB · Serpin 2: “2.8A resolution structure of SRPN2 (K198C) from anopheles gambiae”. X-ray diffraction, 3 pockets (best druggability 0.53). MolNFT v1 #106076 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ROB
Type: protein
Length: 1,063 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serpin 2
UniProt: Q005N3
Pockets: 3 · best druggability 0.53

Structure

x-ray diffraction · 3 distinct chains · 27% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serpin 2	protein	356	28% helix, 33% strand	Q005N3
B	Serpin 2	protein	356	27% helix, 34% strand	Q005N3
C	Serpin 2	protein	351	27% helix, 35% strand	Q005N3

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	188	0.53	0.78	35	empty
2	218	0.49	0.75	38	empty
3	163	0.49	0.78	32	empty

Interfaces

3 interfaces between chains.

A–C · 720 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 642 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 555 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4ROB · 2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q005N3
Elsewhere: RCSB PDB 4ROB · PDBe 4ROB · UniProt Q005N3

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