MolNFT v1 · #106008 · protein

Crystal structure of human ezrin in space group C2221

4RM9: “Crystal structure of human ezrin in space group C2221”. X-ray diffraction, 5 pockets (best druggability 0.69). MolNFT v1 #106008 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4RM9
Type: protein
Length: 368 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ezrin
UniProt: P15311
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ezrin	protein	368	43% helix, 20% strand	P15311

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	343	0.69	0.82	38	empty
2	308	0.59	0.77	26	empty
3	269	0.58	0.78	33	empty
4	65	0.44	0.82	21	empty
5	65	0.32	0.75	12	empty

Compared structures

4RM9 · Crystal structure of human ezrin in space group C2221 · the same entry in another collection · chain A against A, TM-score 1.00
P15311 · AlphaFold monomer V2.0 prediction for ezrin (P15311) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15311
Elsewhere: RCSB PDB 4RM9 · PDBe 4RM9 · UniProt P15311

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