MolNFT v1 · #106007 · protein

Crystal structure of human ezrin in space group P21

4RM8: “Crystal structure of human ezrin in space group P21”. X-ray diffraction, 17 pockets (best druggability 0.69). MolNFT v1 #106007 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4RM8
Type: protein
Length: 735 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ezrin
UniProt: P15311
Pockets: 17 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ezrin	protein	368	44% helix, 20% strand	P15311
B	Ezrin	protein	367	43% helix, 20% strand	P15311

Pockets

17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	316	0.69	0.83	43	empty
2	304	0.69	0.83	41	empty
3	382	0.65	0.79	45	empty
4	305	0.62	0.79	25	empty
5	265	0.57	0.78	35	empty

Interfaces

1 interface between chains.

A–B · 1024 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

4RM8 · Crystal structure of human ezrin in space group P21 · the same entry in another collection · chain A against A, TM-score 1.00
P15311 · AlphaFold monomer V2.0 prediction for ezrin (P15311) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15311
Elsewhere: RCSB PDB 4RM8 · PDBe 4RM8 · UniProt P15311

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