MolNFT v1 · #105998 · protein

Crystal structure of norovirus oif P domain

4RLZ · Capsid protein: “Crystal structure of norovirus oif P domain”. X-ray diffraction, 7 pockets (best druggability 0.80). MolNFT v1 #105998 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4RLZ
Type: protein
Length: 613 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Capsid protein
UniProt: Q6B7R3
Pockets: 7 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Capsid protein	protein	306	6% helix, 35% strand	Q6B7R3
B	Capsid protein	protein	307	6% helix, 36% strand	Q6B7R3

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	497	0.80	0.87	78	empty
2	168	0.78	0.94	28	empty
3	84	0.36	0.76	18	empty
4	72	0.36	0.77	17	empty
5	73	0.30	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 1956 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

4RLZ · Crystal structure of Norovirus OIF P domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6B7R3
Elsewhere: RCSB PDB 4RLZ · PDBe 4RLZ · UniProt Q6B7R3

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