MolNFT v1 · #105934 · protein

Crystal structure of laci family transcriptional regulator from lactobacillus casei, target efi-512911, with bound sucrose

4RK5 · Transcriptional regulator, laci family: “Crystal structure of laci family transcriptional regulator from lactobacillus casei, target efi-512911, with…”. X-ray diffraction, 3 ligands (GLC, FRU, NA), 1 pocket (best druggability 0.78).…

PDB: 4RK5
Type: protein
Length: 275 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulator, laci family
UniProt: Q036L9
Ligands: GLC, FRU, NA
Pockets: 1 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulator, laci family	protein	275	40% helix, 16% strand	Q036L9

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · chains A
FRU · beta-D-fructofuranose · sugar · chains A
NA · Sodium ion · metal · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	342	0.78	0.89	40	GLC, FRU, ACT

Modifications

Observed in the structure: 5 modified (engineered).

Compared structures

4RK5 · Crystal structure of LacI family transcriptional regulator from Lactobacillus casei… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q036L9
Elsewhere: RCSB PDB 4RK5 · PDBe 4RK5 · UniProt Q036L9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.